J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy

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Happy to share my new research on J-difference GABA-edited MRS in HE published in Metabolic Brain Disease. Here we applied GABA-edited MRS to explore metabolic alterations in the cerebello-thalamo-cortical loop in patients with hepatic encephalopthy. GABA+ levels were significanly altered in cerebellum and motor cortex and strongly correlated with critical flicker frequency, motor performance scores and blood ammonia levels. [Read More]

More than one-half of the variance in in vivo proton MR spectroscopy metabolite estimates is common to all metabolites

Do we have to rethink our statistical analysis approaches for 1H-MRS studies? This work by James Prisciandaro suggests that more than half of the total variability in metabolite estimates are explained by a single common factor. The Big PRESS dataset was processed in Osprey and metabolite estimation was performed in LCModel. [Read More]

Neurometabolic timecourse of healthy aging

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New work in NeuroImage from my colleague Tao Gong about the neurometabolic timecourse of healthy aging measured with short TE MRS. This large cross-sectional cohort showed significant correlations for tCho, tCr, mI, and sI in CSO and for NAAG, tCho, tCr, and Gln in PCC. The data was analyzed in Osprey. [Read More]
Tags: LCM MRS MM gLCM