Comparison of seven modelling algorithms for GABA-edited 1 H-MRS

Incredible work by my colleague Alexander Craven on the comparison of seven modelling algorithms for GABA-edited 1 H-MRS now published in NMR in Biomedicine! This work found that moderate agreement between 7 LCM algorthms for GABA-edited MRS extending prior findings on the agreement of LCM in short TE PRESS MRS data. Addtionally, it confirms our recent findings, that including a dedicated MM model for the co-edited macormolecules at 0.9 ppm improves overall quantificaiton in terms of the agreement between different algorithms. [Read More]
Tags: LCM Osprey GABA

Importance of linear combination modeling for quantification of Glutathione and GABA levels using Hadamard-edited MRS

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Happy to share this amazing work of my colleague Yulu Song implying improved quantification accuracy of GABA-GSH-edited HERMES data with linear-combination modeling compared to simple peak fitting. This work strenghtens recent consenus to employ LCM to model edited MRS data. LCM and processing was performed in Osprey and the implemeted models are freely available on GitHub using the accuarlty parametrization of co-edited MMs at 3 ppm to improve general modeling results. [Read More]

In vivo spectral editing of phosphorylethanolamine

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Another exciting paper on edited MRS using LCM for modelling from my colleague Steve Hui. Here two editing schemes to investigate phosphorylethanolamine were implemented on a clincal scanner and analyzed using Osprey. Easy and highly flexible pre-processing and modeling modules in Osprey made this work possible - again showcasing rapid method adaption is possible with open-source implementations such as Osprey. For this work we did implement a new method for sub-spectra alignment into Osprey using a L1 norm optimization across the whole spectral range. [Read More]
Tags: Osprey paper PE