Helge J. Zöllner

Happy to share this amazing work of my colleague Yulu Song implying improved quantification accuracy of GABA-GSH-edited HERMES data with linear-combination modeling compared to simple peak fitting. This work strenghtens recent consenus to employ LCM to model edited MRS data. LCM and processing was performed in Osprey and the implemeted models are freely available on GitHub using the accuarlty parametrization of co-edited MMs at 3 ppm to improve general modeling results. [Read More]

Excited to present our open-source environment for rapid benchmarking of new 1H-MRS methods combining state-of-the-art MRS processing and LCM analysis with Osprey and visualization with SpecVis. [Read More]

Happy to announce that our paper about Linear-combination modeling of GABA-edited MRS is now available at NMR in Biomedicine. A well-parameterized macromolecule (MM) basis function at 3 ppm improved overall modeling performance. [Read More]

Another exciting paper on edited MRS using LCM for modelling from my colleague Steve Hui. Here two editing schemes to investigate phosphorylethanolamine were implemented on a clincal scanner and analyzed using Osprey. Easy and highly flexible pre-processing and modeling modules in Osprey made this work possible - again showcasing rapid method adaption is possible with open-source implementations such as Osprey. For this work we did implement a new method for sub-spectra alignment into Osprey using a L1 norm optimization across the whole spectral range. [Read More]

Happy and proud to have won a poster award for reproducible MRS research at the annual ISMRM MR Spectroscopy Study Group Business Meeting. I presented a pitch on my latest ISMRM abstract ‘Linear-combination modeling of GABA-edited MEGA-PRESS at 3T: Evaluating different modeling strategies’ which is already available as preprint! [Read More]